Bioactive Small Molecules
Cayman Chemical 3-oxo Deoxycholic Acid, Purity: ≥95%, CAS: 4185-01-7, 5 mg
A secondary bile acid; a metabolite of deoxycholic acid in C. perfringens
Medchemexpress LLC Bim BH3 | 505070-06-4 | 99.7% | 2444.77 | 5 MG
Bim BH3 is a biologically active peptide that belongs to the pro-apoptotic Bcl-2 family of proteins. It is for research use only and not sold to patients.
- Biologically active peptide
- Belongs to the pro-apoptotic Bcl-2 family of proteins
- Intended for research use only
- Functions as an inhibitor
![Medchemexpress LLC 2-((ethyl(4-fluorophenyl)amino)methyl)-7,8-dihydro-4H,6H-cyclopentathiazolo[3,2-a]pyrimidin-4-one | 1698901-76-6 | 98.9% | 343.42 g·mol⁻¹ | C18H18FN3OS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240609.png-250.jpg)
Medchemexpress LLC 2-((ethyl(4-fluorophenyl)amino)methyl)-7,8-dihydro-4H,6H-cyclopentathiazolo[3,2-a]pyrimidin-4-one | 1698901-76-6 | 98.9% | 343.42 g·mol⁻¹ | C18H18FN3OS | 1 ML
GNE-8324 is a selective GluN2A positive allosteric modulator of NMDA receptors. It selectively enhances NMDAR-mediated synaptic responses in inhibitory neurons but not excitatory neurons, and is used as a research tool to probe GluN2A-dependent receptor function.
- Selective GluN2A positive allosteric modulator
- Enhances NMDAR-mediated synaptic responses in inhibitory neurons
- Useful tool for studying GluN2A-dependent NMDA receptor pharmacology
- Offered as a 10 mM solution in DMSO (1 mL) and as solid quantities
- High purity, approximately 98.9%
- Molecular formula C18H18FN3OS and molecular weight 343.42 g·mol⁻¹
- Storage recommendations provided for powder and solvent to preserve stability
eMolecules 2226521-65-7 | Medchem Express | FM-381 | 5mg | 446257625 | HY-102046 | 428.496 | C24H24N6O2
Ambeed | 2-(3-Bromo-4-fluorophenyl)acetonitrile | 1g | 503282088 | A232105 | 501420-63-9 | MFCD08458154 | 214.037 | C8H5BrFN
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Medchemexpress LLC 2R 7aS -2-Fluorotet 1g
(2R 7aS)-2-Fluorotetrahydro-1H-pyrrolizine-7a(5H)-methanol is a drug intermediate for synthesis of various active compounds (2R 7aS)-2-Fluorotetrahydro-1H-pyrrolizine-7a(5H)-methanol is a core structural framework of the compounds targeting KRAS G12D mutation
Cayman Chemical Desmethyl Bosentan, Purity: ≥95%, CAS: 253688-61-8, 5 mg
An active metabolite of bosentan; activates the PXR in a reporter assay at 25 µM
Medchemexpress LLC 3'-O-Me-G(iBu)-2'-phosphoramidite | 179479-04-0 | C45H56N7O9P | 50 MG
3'-O-Me-G(iBu)-2'-phosphoramidite is a guanosine analog that exhibits immunostimulatory activity. In some animal models, it induces type I interferons, leading to antiviral effects. Its functional activity depends on the activation of Toll-like receptor 7 (TLR7).
- Guanosine analog
- Exhibits immunostimulatory activity
- Induces type I interferons in animal models
- Leads to antiviral effects
- Functional activity dependent on activation of Toll-like receptor 7 (TLR7)
Medchemexpress LLC Acid-PEG8-S-S-PEG8-a 50mg
Acid-PEG8-S-S-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC HY-112584 100mg Medchemexpress, JBSNF-000088 CAS:7150-23-4 Purity:>98%
Medchemexpress, HY-112584 100mg JBSNF-000088 CAS:7150-23-4 JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC GLP-1 receptor agonist 11 | 2784590-83-4 | C31H31ClFN3O4 | 25 MG
GLP-1 receptor agonist 11 (compound 3) is an agonist of GLP Receptor. It is utilized in the study of diseases such as diabetes and non-alcoholic fatty liver disease. This product is intended for research use only.
- Agonist of GLP receptor
- Used in research for diabetes and non-alcoholic fatty liver disease
- Purity: 98.01%
- Appearance: solid, white to off-white
- Stable under recommended storage conditions
- For research use only
Cayman Chemical 4A7C-301-Nurr1 Agonist, Purity: ≥98%, 1 mg
A Nurr1 receptor agonist; binds to Nurr1-LBD (IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively); decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in MPTP- or α-synuclein-overexpression mouse models of Parkinson’s disease
Medchemexpress LLC Benzo[lmn]phenanthroline-1,3,6,8(2H,7H)-tetrone, 2,7-bis(4-hydroxybutyl)- | 298217-59-1 | C22H22N2O6 | 5 MG
MMV009085 is a potent Plasmodium falciparum hexose transporter (PfHT1)-specific inhibitor and a potential anti-malarial agent. It also acts as a human glucose transporter inhibitor, demonstrating high potency in inhibiting both glucose uptake (IC50: 2.6 μM) and the growth of parasites (EC50: 1.23 ± 0.04 μM against 3D7).
- Potent PfHT1-specific inhibitor
- Potential anti-malarial agent
- Human glucose transporter inhibitor
- High potency in inhibiting glucose uptake (IC50: 2.6 μM)
- Inhibits growth of various parasite strains (EC50: 1.23 ± 0.04 μM; 0.720 ± 0.05 μM)
- Inhibits transport activity of PfHT-1 (IC50: 212 ± 39 μM)
- Shows cytotoxicity against HEK293T cells (CC50: 2.46 ± 0.03 μM) and HepG2 cells (CC50: 1.92 ± 0.85 μM)
- Acts through PfHT blockage to inhibit parasite growth (EC50 = 0.795 μM)
Cayman Chemical YU238259, Purity: ≥95%, CAS: 1943733-16-1, 1 mg
An inhibitor of homology-dependent DNA repair; lethal to BRCA2-/- but not BRCA2+/+ PEO1/4 cells (LD50s = 8.7 and >100 μM, respectively); selectively inhibits HDR over NHEJ; decreases the number of U20S cells with ionizing radiation-induced BRCA1 foci but not 53BP1 or pDNA-PK foci; increases the number of ionizing radiation-induced DSBs in DLD-1 cells; cytotoxic to BRCA2-/- DLD-1, ATM-/- GM05849, and PTEN-/- U251 cells from 1-20 μM; delays tumor growth and increases survival in a BRCA2-/-, but not a BRCA+/+, DLD-1 mouse xenograft model at 3 mg/kg
Cayman Chemical TC 14012 (hydrochloride), Purity: ≥95%, 5 mg
A CXCR4 antagonist (IC50 = 2.9 nM) and CXCR7 agonist; induces β-arrestin recruitment in HEK293T cells expressing CXCR7 (EC50 = 350 nM); reduces the cytopathic effect of HIV in infected MT-4 cells (EC50 = 0.4 nM); inhibits HIV entry in vitro in a CXCR4-dependent manner (IC50 = 19.3 nM); inhibits CXCL12-induced migration in MDA-MB-231 cells and HUVECs from 10-1,000 nM; decreases infarct size in a mouse model of LAD coronary artery ligation-induced acute myocardial infarction at 10 mg/kg
Cayman Chemical Bicyclol, Purity: ≥98%, CAS: 118159-48-1, 1 mg
A hepatoprotective agent; reduces viral DNA and the secretion of HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells; reduced DHBV DNA in DHBV-infected ducks at doses ≥0.4 g/kg; reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of concanavalin A-induced liver injury; prevents formation of DEN/PB-induced hepatocellular carcinomas; reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis