Bioactive Small Molecules
AdipoGen (±)-Naringenin (25 g)
Chemical. CAS: 67604-48-2. Formula: C15H12O5. MW: 272.25. Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes. It has a broad panel of properties, including antibacterial, antiviral, antifungal, anti-inflammatory, antioxidant, anticancer, antidiabetic, cardioprotective and neuroprotective activities. Naringenin activity is primarily attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and inflammatory transcription factors) and antioxidant (via scavenging of free radicals, bolstering of endogenous antioxidant defense system and metal ion chelation) effects. Naringenin exerts its anti-diabetic effects by inhibition of gluconeogenesis through upregulations of AMPK, leading to its lipid lowering and insulin-like properties.
Cayman Chemical galacto-DapaglIflozIn 5mg
A potent inhibitor of human SGLT2 that is 1,000-fold less potent at human SGLT1 (Ki values are 2 and 25,000 nM, respectively); dissociates from hSGLT2 more slowly than from hSGLT1 (half-time off rates are 19 and 0.9 seconds, respectively)
AdipoGen Tofacitinib citrate (5 mg)
Chemical. CAS: 540737-29-9. Formula: C16H20N6O . C6H8O7. MW: 312.4 . 192.1. Synthetic. Tofacitinib citrate is a potent cell permeable JAK3 inhibitor (IC50=1nM), which Shows also JAK-1 inhibitory activity. This is an immunosuppressive and anti-inflammatory agent. It inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. It also has been shown to be a potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 1 G
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. This product also functions as a click chemistry reagent, containing an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Functions as a PEG-based PROTAC linker
- Utilized in the synthesis of BTK-CRBN PROTACs
- Acts as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition
Grainger Rotary Hammer 11A @ 120V 260 rpm
The Milwaukee 822AG4 is a 1-9/16" SDS-Max rotary hammer drill that delivers 4.7 ft-lbs of impact energy for heavy-duty drilling and chiseling in concrete and masonry. It has a powerful 12 amp motor that provides 0-1,100 RPM and 0-4,500 BPM. The rotary hammer has a keyless chuck for quick bit changes and an anti-vibration side handle for comfort. It weighs 17.2 lbs and comes with a contractor bag. The 822AG4 is ideal for concrete drilling, chipping and chiseling applications.
AdipoGen Semaglutide (5 mg)
Chemical. CAS: 910463-68-2. Formula: C187H291N45O59. MW: 4114.6. Glucagon-like peptide-1 (GLP-1) receptor agonist. Antidiabetic agent against type 2 diabetes (T2D). Stimulates insulin and suppresses glucagon secretion in a glucose-dependent manner. Longer-acting alternative to liraglutide. Chemically similar to glucagon-like peptide-1 (GLP-1), with two amino acid substitutions compared to human GLP-1 (Aib(8), Arg(34)) and derivatized at lysine 26. Antiobesity activity. Reduces energy intake, likely mechanisms for semaglutide-induced weight loss include less appetite and food cravings, better control of eating and lower relative preference for fatty, energy-dense foods.
Apexbio Technology LLC Dantrolene, sodium salt 14663-23-1 100mg
Dantrolene sodium salt (CAS 14663-23-1) is a small-molecule antagonist of the ryanodine receptor (RyR) exhibiting an IC50 of 5 9 0 3 nM for RyR2 RyRs located on the endoplasmic and sarcoplasmic reticulum regulate intracellular Ca sup 2 /sup release and their dysregulation contributes to conditions such as ischemia neurodegenerative diseases and trauma In mouse cardiomyocytes dantrolene reduced Ca sup 2 /sup wave frequency and amplitude in the presence of calmodulin indicating calmodulin dependence for RyR inhibition In in vivo models of pancreatitis dantrolene decreased pancreatic trypsin activity and serum amylase supporting its use in research on calcium-mediated cellular injury
TARGETMOL CHEMICALS INC R-ZANUBRUTINIB 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK). purity: 98%
Cayman Chemical DIlazephydrochlorIde 5mg
An ENT1 inhibitor (IC50 = 17.5 nM); selective for ENT1 over ENT2 (IC50 = 8,800 nM); increases adenosine-induced relaxation of isolated guinea pig taenia caeci strips at 0.03 and 0.3 µM; decreases calcium-induced contractions in isolated guinea pig taenia caeci strips at 1, 5, and 10 µM; reduces heart rate and systolic, mean, and diastolic aortic pressure and increases left ventricular blood flow in anesthetized dogs at 0.2 mg/kg, i.v.; reduces aortic platelet adhesion and aggregation in a rabbit model of aortic injury-induced thrombosis at 0.1 mg/kg
Cayman Chemical ANTIBODY GRI-977143 25mg
An LPA2 receptor agonist (EC50 = 3.3 μM in LPA2-transfected RH7777 cells); selective for LPA2, having no activity at LPA1, LPA3, LPA4, and LPA5 at concentrations up to 10 μM; increases growth and reduces caspase-3 and -7 activation in LPA2-transduced MEF fibroblasts; increases MM1 rat hepatoma cell invasion and inhibits apoptosis of IEC-6 cells induced by TNF-α, doxorubicin, or serum withdrawal; rescues apoptotic cells from γ-irradiation-induced injury in vitro and in vivo
Medchemexpress LLC HY-13417 200mg , AICAR CAS:2627-69-2 Purity:>98%
HY-13417 200mg AICAR CAS: 2627-69-2 AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY DImInutol 1mg
A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to depolymerize microtubules and disrupt mitosis
Cayman Chemical ANTIBODY MIglItol 50mg
An inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 μM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively); selective for α- over β-glucosidase (IC50 = 84 μM); decreases blood glucose levels in sucrose-loaded GK type 2 diabetic rats at 10 mg/kg; dietary administration decreases changes in HbA1c levels compared with control rats fed a normal diet 40 mg/100 g diet
Cayman Chemical ANTIBODY HPOB 1mg
A potent, selective inhibitor of HDAC6 (IC50 = 56 nM); induces acetylation of α-tubulin but not histones; enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft
Cayman Chemical ANTIBODY TIC10 10mg
Induces the expression of TRAIL at 1-5 µM in a p53-independent manner; orally active, stable, and crosses the blood-brain barrier; suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice